Sunday May 22
14:00-15:15 Registration open

15:15 Opening
Chair: Marcel Tijsterman

15:20-16:00 Tom Kunkel (NIH, USA)
”Eukaryotic DNA Replication Fidelity by the B-Family DNA Polymerases”

16:00-16:30 Joanne Sweasy (University of Arizona, USA)
”Fidelity Mechanisms of DNA Polymerase Beta”

16:30-17:00 Wei Yang (The National Institutes of Health, USA)
“Flexible substrate binding and multiple deprotonation paths of DNA polymerases”

17:00-17:30 Coffee/tea break

17:30-18:00 Katarzyna Bebenek (NIEHS, USA)
”Structural Insights into How Polymerase Lambda Engages DNA Double Strand Breaks”

18:00-18:20 Erik Johansson (Umeå University, SE)
”In crystallo study of the reaction mechanism in a family B DNA polymerase”

18:40 Dinner at the Wenner-Gren Centre

Monday May 23
Chair: Sjoerd Wanrooij

09:00-09:30 William Copeland (NIEHS, USA)
“New insights into mitochondrial DNA replication”

09:30-09:50 Josefin Forslund (Umeå University, SE)
”The disease mechanism of DNA polymerase gamma Y951N mutation”

09:50-10:10 María Isabel Martínez-Jiménez (Centro de Biología Molecular Severo Ochoa, ES)
“Human PrimPol evades ddCTP and tenofovir nucleotide analogs and relieves mitochondrial toxicity”

10:10-10:50 Coffee/tea break

10:50-11:20 Maria Falkenberg (University of Gothenburg, SE)
“Molecular basis of mitochondrial DNA replication in mammalian cells”

11:20-11:40 Margaret Gustafson (NIEHS, USA)
“Mechanisms of SSBP1 variants in mitochondrial disease: Molecular dynamics simulations reveal stable tetramers with altered DNA binding surfaces”

11:40-12:00 Anders Clausen (University of Gothenburg, SE)
“Stably incorporated ribonucleotides in murine tissues: quantitation, base identity and distribution in nuclear and mitochondrial DNA”

12:00-13:50 Lunch

Chair: Julian Sale

13:50-14:20 Polina Shcherbakova (University of Nebraska, USA)
”DNA polymerase ε variants in cancers: new insights into the mechanisms of pathogenicity”

14:20-14:50 Zac Pursell (Tulane University, USA)
“Insights Into Polymerase-Mediated Mutagenesis and Tumorigenesis From Mouse Models, Cell Culture and Human Patients”

14:50-15:10 Sean Rudd (Karolinska Institute, SE)
”Inhibiting the dNTP hydrolase SAMHD1”

15:10-15:30 Andrei Chabes (Umeå University, SE)
“Regulation of dNTP pools in response to DNA damage”

15:30 Coffee/tea

18:15 Transport to Vasa Museum
19:00 Guided tour and Dinner (around 20:00) at the Vasa Museum

Tuesday May 24
Chair: Peter Burgers

09:00-09:30 Meindert Lamers (Leiden University, Medical Center, NL)
“A four-point molecular hand-off during Okazaki fragment maturation in E. coli

09:30-09:50 Ceslovas Venclovas (Vilnius University, LT)
”New insights obtained from computational analysis of DNA polymerases in complete bacterial genomes”

09:50-10:10 Janice Pata (University of Albany, USA)
”Kinetic mechanisms of Staphylococcus aureus DNA polymerases PolC and DnaE: Insights into the initiation of DNA synthesis in Gram-positive bacteria”

10:10-10:30 Ignacio Mir Sanchis (Umeå University, SE)
“DNA polymerases in the Staphylococcal metaverse”

10:30-10:50 Coffee/tea break

Chair: Erik Johansson

10:50-11:20 Wolf-Dietrich Heyer (University of California, USA)
”BRCA2 and RAD52 inhibit DNA Polymerase q to enforce DSB repair pathway choice”

11:20-11:40 Kei-ichi Takata (Institute for Basic Science, KR)
“DNA polymerase theta mediated repair of high LET radiation-induced DNA double strand breaks”

11:40-12:00 Joost Schimmel (Leiden University, Medical Center, NL)
“CST-guided Polymerase a-primase action at DNA breaks induces small tandem duplications and prevents large deletions”

12:00-13:50 Lunch

13:50-14:20 Sylvie Doublié (University of Vermont, USA)
“Structural and biochemical investigation of Pol θ’s unique functions”

14:20-14:50 Marcel Tijsterman (Leiden University, NL)
“Polymerase theta-mediated end joining biology”

14:50-15:10 Andrea Kaminski (NIEHS, USA)
“Structural snapshots of human DNA polymerase µ engaged on a DNA double-strand break”

15:10-18:30 Poster viewing

18:30 Dinner at the Wenner-Gren Center

Wednesday May 25
Chair: Wolf-Dietrich Heyer

09:00-09:40 John Diffley (Francis Crick Institue, UK)
“Understanding Eukaryotic Chromosome Replication through Biochemical Reconstitution”

09:40-10:00 Giovanni Maga (Institute of Molecular Genetics IGM CNR, IT)
“The Jigsaw puzzle of hybrid RNA-DNA genome tolerance pathways”

10:00-10:20 Kelly Zatopek (New England Biolabs)
“Unmasking the Ribonucleotide Steric Gate in Family D DNA Polymerases”

10:20-10:50 Coffee/tea break

Chair: Polina Shcherbakova

10:50-11:20 Peter Burgers (Washington University St Louis, USA)
“The lame leading the blind: Rev1-DNA polymerase zeta in TLS”

11:20-11:50 Vincent Pages (CNRS, FR)
“Control of TLS DNA polymerases in response to genotoxic stress: global or local regulation?”

11:50-12:10 Dmitry Korzhnev (University of Connecticut Health Center, USA)
“Evolution of Rev7 interactions in eukaryotic TLS DNA polymerase Pol”

12:10-14:00 Lunch

Chair: Andrei Chabes

14:00-14:30 Luis Blanco (Centro de Biología Molecular Severo Ochoa, ES)
“The mechanism of DNA primer synthesis by human PrimPol”

14:30-14:50 Sjoerd Wanrooij (Umeå University, SE)
“PolDIP2 enhances nucleotide binding and DNA synthesis by PrimPol”

14:50-15:10 Tatiana Moiseeva (Tallinn University of Technology, EE)
“Using mAID-mediated depletion of DNA polymerase epsilon to uncover its non-catalytic role in human cell”

15:10-15:30 Sellés-Baiget Selene (NNF Center for Protein Research, DK)
“Non-catalytic function of DNA polymerase κ during lesion bypass”

15:30-16:00 Coffee/tea break

16:00-16:30 Julian Sale (MRC Cambridge, UK)
“The mutagenic footprint of DNA replication origins”

16:30-17:00 Pat Foster (Indiana University Bloomington, USA)
”Insights into the fidelity of DNA replication gained from mutation accumulation studies in Escherichia coli

17:00-17:20 Ludovic Sauguet (Institut Pasteur, FR)
“New Insights on the D-family archaeal replicative DNA polymerase: structure, evolution and interactions with its replisome partners”

17:20-17:40 Tahir Tahirov (University of Nebraska Medical Center, USA)
“Mechanism of Primase-Polalpha termination”

17:40-17:50 Erik Johansson and Sjoerd Wanrooij “on the 7th DNA Polymerases Meeting” and closure

18:00 Dinner at Wenner Gren Center

Thursday May 26